MICROSATELLITE INSTABILITY AT U2AF-BINDING POLYPYRIMIDIC TRACT SITES PERTURBS ALTERNATIVE SPLICING DURING COLORECTAL CANCER INITIATION

Microsatellite instability at U2AF-binding polypyrimidic tract sites perturbs alternative splicing during colorectal cancer initiation

Abstract Background Grill Racks Microsatellite instability (MSI) due to mismatch repair deficiency (dMMR) is common in colorectal cancer (CRC).These cancers are associated with somatic coding events, but the noncoding pathophysiological impact of this genomic instability is yet poorly understood.Here, we perform an analysis of coding and noncoding

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Recent insights into therapeutic potential and nanostructured copyright systems of Centella asiatica: An evidence-based review

Introduction: Centella asiatica (L.) Urb.is an authentic herbal medicine that is frequently used in Southeast Asian regions and scientific investigations have demonstrated the benefits of Centella asiatica and its constituents in various health issues.The active constituents of Centella asiatica are pentacyclic triterpenoid (asiatic acid, adecassic

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Importance of the layered structure of leaves on the determination of their scattering and absorption properties

The influence of the layered structure of plant leaves on the optical properties obtained with a homogeneous theoretical model was investigated.To this aim, silicone phantoms with different optical properties modeling synthetic leaf layers were fabricated to study a two-layer model of the leaf.The optical properties were determined with spectrally

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