Microsatellite instability at U2AF-binding polypyrimidic tract sites perturbs alternative splicing during colorectal cancer initiation
Abstract Background Grill Racks Microsatellite instability (MSI) due to mismatch repair deficiency (dMMR) is common in colorectal cancer (CRC).These cancers are associated with somatic coding events, but the noncoding pathophysiological impact of this genomic instability is yet poorly understood.Here, we perform an analysis of coding and noncoding